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Department of Justice, Antitrust Division
Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic
At higher doses, some people experienced more intense digestive side effects, and in a larger phase 3 trial, about 12 to 18% of people stopped treatment because of side effects
Future GLP-2 trials in IBD should stratify patients by disease phenotype (mucosal UC, inflammatory CD, stricturing CD) and incorporate serial cross-sectional imaging to monitor for stricture progression, given the mechanistic link between GLP-2R signaling through subepithelial myofibroblasts and intestinal fibrogenesis
The study in the European Heart Journal involved 113 healthy men and women to determine the effect of consuming red meat and white meat (such as chicken or turkey) on TMAO levels
